ICR Research Department is carrying out a clinical trial lead by Dr. Castillo with patients affected by Leber Hereditary Optic Neuropathy

Medical content revised by - Last revision 21/11/2018
ICR Research Department is carrying out a clinical trial lead by Dr. Castillo with patients affected by Leber Hereditary Optic Neuropathy

ICR, at the forefront of research

Dr Castillo, Head of Neuro-Ophthalmology and Teaching Department at Institut Català de Retina, has initiated, alongside the Research Department, a clinical trial developed by Santhera Pharmaceuticals, for which participants affected by Leber Optic Neuropathy (LHON), older than 12 years old and of all genders, are being recruited. The disease must have triggered in the last five years and patients affected must have any of the common mutations (G11778A, G3460A o T14484C).

What kind of disease is Leber’s optic neuropathy?

Leber’s optic neuropathy is a neurodegenerative mitochondrial disease that affects the optic nerve and is characterized by a sudden vision loss in young adults that are genetic carriers of the disease. LHON is considered an Orpha disease, which means is a rare disease.

Its prevalence is really low, and not all mutation carriers developed the symptoms. This means the participant search for the trial is an essential task. Moreover, since it is a mitochondrial disease, only women transmit it genetically to their children, while men carriers do not transmit it.

Other current NOHL researches

Dr Castillo, besides leading the research, has also studied the disease in the editorial Leber Hereditary Optic Neuropathy: what therapeutic perspectives do we have? that will be published shortly in the journal Archivos de la Sociedad Española de Oftalmología, and where she analyses and provides her opinion on new therapeutic perspectives for the disease.

The clinical trial, which is currently in participant recruitment phase, is being carried out at a European level, and in Catalonia, Institut Català de Retina is the only centre the develops it. In Spain, only another centre is also performing the trial.

Clinical trial and exclusion criteria

Before participating in the trial, there are several exclusion criteria to highlight, especially having previously undergone a treatment with idebenone. If you wish to read further on the trial, you can check the clinical trial’s website, officially registered at the USA National Health Institute.


If you want to discuss a possible participation to the trial, please contact:

Dr Lorena Castillo: 36918lcc@gmail.com

Post your comment

In accordance with the provisions of the General Data Protection Regulation (REGULATION (EU) 2016/679), the following information about the processing of personal data is disclosed to you.

Responsible: Institut Català de la Retina, S.L., Institut Català de Cirurgia refractiva, S.L. (from now on ICR)

Representative of Data Protection Contact: C/Pau Alcover nº 67 08017 Barcelona – rgpd@icrcat.com

Aim: The purpose of the treatment is to manage the information you provide us and after having your consent, publish the testimonial on our website.

Legitimization: The legal basis for the present treatment is the request made by you and having your consent.

Recipients: The recipients of the information are the departments and delegations in which ICR is organized, in part or in its entirety. It will not be communicated to third parties.

Rights: At any time, you can exercise your rights of access, rectification, deletion, opposition, limitation of treatment and / or portability of data by writing to the RPD Representative of Data Protection at the address provided in contact. You can also revoke consents to other treatments. You can also request more information from the RPD about the treatments performed.
In the event that you consider that your rights have been violated, you can submit a claim to the competent Data Protection Control Authority.

For all purposes, the user accepts that the opinion expressed will be exclusively his /her responsibility. The user assumes under his / her exclusive responsibility the damages or harms that may derive from it.
ICR will not be responsible for the accuracy, quality, reliability, correctness, morality and legality of the data, information or opinions published by users.
ICR reserves the right not to publish all opinions of users.
The user is solely responsible of his /her username. ICR will not be responsible for the illegal use or for illicit purposes that other users can make of this user name.

Preservation: The collected data will be kept during the time required for the requested management, for at most 30 days.


ICR Ganduxer Headquarters

08022 Barcelona

ICR Pau Alcover

C. Pau Alcover 67
08017 Barcelona

ICR Terrassa

C. del Nord, 77
08221 Terrassa

Clínica Bonanova Surgical Center

Passeig Bonanova, 22
08022 Barcelona

Clinica Bonanova Tests and Treatments

c/ Mandri, 63
08022 Barcelona

ICR Service at Clínica Ntra. Sra. del Remei

c/ de l'Escorial,148
08024 Barcelona
This website uses cookies in order to collect statistical information regarding navigation. If you keep on surfing this website, it shall be deemed to have acknowledged its use. More information.